The scientific committees that review these studies in the United States and Europe are associated with organizations such as the European Commission Scientific Committee for Cosmetic Products and Non-Food Products (SCCNFP); Cosmetics, Toiletries, and Fragrance Association (CTFA); the European Cosmetic Toiletry and Perfumery Association (COLIPA); the Environmental Protection Agencies (EPA); the Food and Drug Administration (FDA); and the American Medical Association (AMA), to name a few. These review boards are made up of unbiased and qualified scientists and professionals that understand the methods of scientific research and are experts in their fields. These committees examine available studies on a given ingredient and determine human safety applications and environmental impact when used in cosmetics. The CTFA provides ingredient safety information to the cosmetic industry through the Cosmetic Ingredient Review board (CIR), a program established in 1976 to assess cosmetic ingredient safety in an unbiased, independent forum. The CIR is comprised of an expert panel of respected physicians and scientists. Ice Elements and our laboratory are members of the Cosmetic Toiletries and Fragrance Association, The Cosmetics Chemists Association and respect and follows the CIR recommendations and findings. According to the CIR panel, as printed in the Journal of the American College of Toxicology, Butylene glycol is "safe as presently used in cosmetics." The report goes on to say that repeated insult patch tests on butylene glycol produced no evidence of skin sensitization.